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CHILDRENS MIGRELIEF Lifestyle Interactions
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Lapatinib 250mg, Oral tablet
• Interaction: Grapefruit juice• Severity: Major• Notes for Consumers: Do not take Lapatinib with Grapefruit or Grapefruit juice. Side effects of Lapatinib may get worse. If you accidentally take Lapatinib with grapefruit or grapefruit juice, immediately tell your doctor about any unusual effects.• Notes for Professionals: Avoid administration of lapatinib with grapefruit juice due to increased plasma concentrations of lapatinib. Lapatinib is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Concomitant use with another strong CYP3A4 inhibitor increased lapatinib exposure by 3.6-fold and increased the half-life of lapatinib by 1.7-fold.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
