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    • ESTRADIOL (ONCE WEEKLY) (Generic for CLIMARA)

ESTRADIOL (es tra DYE ole) reduces the number and severity of hot flashes due to menopause. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. It can be used to prevent osteoporosis. It works by increasing levels of the hormone estrogen in the body. It is an estrogen hormone.


ESTRADIOL (ONCE WEEKLY) (Generic for CLIMARA) Lifestyle Interactions

  • Eplerenone 25mg, Oral tablet

    Interaction: Grapefruit juice
    Severity: Severe
    Notes for Consumers: Do not take these drugs together. Discuss possible alternative treatment options with your prescriber. Taking these drugs together can increase the amount of Eplerenone in your blood and may cause your blood pressure to be too low or increase the amount of potassium in your blood. When there is too much potassium in the blood it can cause muscle weakness or an abnormal heart rhythm.
    Notes for Professionals: Concomitant use of grapefruit or grapefruit juice and eplerenone is contraindicated. Grapefruit potently inhibits the hepatic CYP3A4 isoenzyme and may increase serum eplerenone concentrations by about 25% and, hence, can increase the risk of developing eplerenone-induced hyperkalemia and hypotension.

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.