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HISTRELIN (his TREL in) treats a condition that causes early puberty. It works by decreasing levels of the hormones estrogen and testosterone in the body. This slows or stops signs of puberty while you are taking this medication.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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This medication is placed under the skin of your arm by your care team in a clinic or office. After the implant is placed, keep the insertion site clean and dry for 24 hours. Avoid heavy lifting and strenuous exercise for 7 days after implant insertion. The surgical strips over the site should be allowed to fall off on their own over several days. The implant must be removed after 12 months. At this time, a new implant may be inserted to continue therapy.
A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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-Certain medications for depression, anxiety, or other mental health conditions
-Estrogen or progestin hormones
-Supplements, such as black cohosh or DHEA
-Male hormones, like testosterone
-Prasterone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. In the first few weeks of treatment, signs of puberty may increase for a short time. Tell your care team if your symptoms do not start to get better or if they get worse after several weeks.
Keep an eye on the incision site until it heals. Talk to your care team right away if there is severe pain, redness, swelling, bleeding around the implant site or if the implant comes through the skin.
Talk to your care team if you may be pregnant. Serious fetal side effects can occur if you take this medication during pregnancy.
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This does not apply. After 1 year, the implant will have to be removed. If you need to continue this medication, the implant will be replaced at that time.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
-Redness, blistering, peeling, or loosening of the skin, including inside the mouth
-Rapid or extreme change in emotion or mood
-Rash, fever, and swollen lymph nodes
-Seizures
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Pain, redness, irritation, or bruising at the injection site
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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This medication is given in a hospital or clinic. It will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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