ZENBEXUS

IBERDOMIDE (eye BER doe mide) treats multiple myeloma, a type of bone marrow cancer. It works by slowing down the growth of cancer cells.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. You can take it with or without food. If it upsets your stomach, take it with food. Your care team may change your dose, temporarily stop treatment, or stop treatment completely if you have side effects. Do not change your dose or stop taking this medication unless your care team tells you to. Keep taking it unless your care team tells you to stop.
Each bottle contains capsules and a drying agent (desiccant) to keep the capsules dry. Keep the drying agent canister in the bottle. Do not eat it.
Handling this medication may be harmful. Talk to your care team about how to handle this medication. Special instructions may apply. If you touch a broken capsule or the medication inside the capsule, wash the area of your body right away with soap and water.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

-Grapefruit and foods or drinks that contain grapefruit
-Some antibiotics, such as ciprofloxacin, clarithromycin, erythromycin, rifampin
-Some medications for cancer, such as apalutamide, dabrafenib, enzalutamide, imatinib, nilotinib
-Some medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-St. John's wort
Other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your care team for regular checks on your progress. This medication may make you feel generally unwell. This is not uncommon in medications used to treat cancer. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop.
You may need blood work done while you are taking this medication.
This medication can increase your risk of developing serious blood clots. These clots can form in the legs or lungs. Blood clots can block blood flow to the heart or brain, causing a heart attack or stroke. Your care team will assess your risk. They may prescribe a medication to help prevent blood clots while you are this medication. It is important to follow the directions from your care team.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication.
Talk to your care team if you or your partner may be pregnant. Serious fetal side effects can occur if you take this medication during pregnancy and for 4 weeks after the last dose. You will need 2 negative pregnancy tests before starting this medication. You will also have routine pregnancy tests while taking this medication. Contraception is recommended before starting this medication, during treatment, and for 4 weeks after the last dose. Your care team can help you find the option that works for you. Stop taking this medication and contact your care team right away if you miss your period, have unusual bleeding, stop using contraception, or think you may be pregnant.
If your partner can get pregnant, use a condom during sex while taking this medication and for 4 weeks after the last dose. Tell your care team right away if your partner becomes pregnant while you are taking this medication.
Do not donate sperm or eggs while taking this medication and for 4 weeks after the last dose.
Do not donate blood while you are taking this medication and for 4 weeks after the last dose. Donated blood may contain enough of this medication to cause serious fetal side effects if transfused to someone who is pregnant.
Do not breastfeed while taking this medication.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

If you miss a dose, take it as soon as you can unless it is more than 12 hours late. If it is more than 12 hours late, skip the missed dose. Take your next dose at the normal time. Do not take double or extra doses.

Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
-Body pain, tingling, or numbness
-Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
-Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
-Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
-Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
-Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Diarrhea
-Fatigue
-Loss of balance or coordination
-Muscle pain
-Muscle weakness
-Numbness, decrease in sense of touch or sensation
-Skin rash
-Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original container until you are ready to take it. Protect from moisture. Keep the container tightly closed. Do not throw out the canister in the container. It keeps the medication dry. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, ask your pharmacist or care team how to get rid of it safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.