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VENLAFAXINE (VEN la fax een) treats depression and anxiety. It increases the amount of serotonin and norepinephrine in the brain, hormones that help regulate mood. It belongs to a group of medications called SNRIs.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with a full glass of water. Take it as directed on the prescription label. Do not cut, crush, or chew this medication. Take it with food. You may open the capsule and put the contents in 1 teaspoon of applesauce. Swallow the medication and applesauce right away. Do not chew the medication or applesauce. Follow with a glass of water to ensure complete swallowing of the pellets. Try to take your medication at about the same time each day. Do not take your medication more often than directed. Keep taking this medication unless your care team tells you to stop. Stopping it too quickly can cause serious side effects. It can also make your condition worse.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Alcohol
-Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
-Cisapride
-Desvenlafaxine
-Dronedarone
-Duloxetine
-Levomilnacipran
-Linezolid
-MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, and Parnate
-Methylene blue (injected into a vein)
-Milnacipran
-Pimozide
-Thioridazine
This medication may also interact with the following:
-Amphetamines
-Aspirin and aspirin-like medications
-Certain medications for mental health conditions
-Certain medications for migraine headaches, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
-Certain medications for sleep
-Certain medications that treat or prevent blood clots, such as dalteparin, enoxaparin, warfarin
-Cimetidine
-Clozapine
-Diuretics
-Fentanyl
-Furazolidone
-Indinavir
-Isoniazid
-Lithium
-Metoprolol
-NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
-Other medications that cause heart rhythm changes
-Procarbazine
-Rasagiline
-Supplements, such as St. John's wort, kava kava, valerian
-Tramadol
-Tryptophan
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Tell your care team if your symptoms do not get better or if they get worse. Visit your care team for regular checks on your progress. Because it may take several weeks to see the full effects of this medication, it is important to continue your treatment as prescribed by your care team.
Watch for new or worsening thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.
This medication may cause mood and behavior changes, such as anxiety, nervousness, irritability, hostility, restlessness, excitability, hyperactivity, or trouble sleeping. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you notice any of these symptoms.
This medication can cause an increase in blood pressure. Check with your care team for instructions on monitoring your blood pressure while taking this medication.
This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.
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If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Bleeding—bloody or black, tar-like stools, red or dark brown urine, vomiting blood or brown material that looks like coffee grounds, small, red or purple spots on skin, unusual bleeding or bruising
-Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
-Increase in blood pressure
-Loss of appetite with weight loss
-Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion
-Serotonin syndrome—irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizures, chills, vomiting, diarrhea
-Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
-Thoughts of suicide or self-harm, worsening mood, feelings of depression
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
-Anxiety, nervousness
-Change in sex drive or performance
-Dizziness
-Dry mouth
-Excessive sweating
-Nausea
-Tremors or shaking
-Trouble sleeping
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at a controlled temperature between 20 and 25 degrees C (68 degrees and 77 degrees F), in a dry place. Throw away any unused medication after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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