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LOMITAPIDE (loe MI ta pide) treats high cholesterol. It works by reducing the amount of cholesterol made by your body. Changes to diet and exercise are often combined with this medication.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. If you can't swallow them whole, you can open the capsule and put the contents on 1 tablespoon of applesauce or mashed banana. Take this medication on an empty stomach, at least 2 hours after the evening meal. Keep taking it unless your care team tells you to stop.
Do not take this medication with foods or drinks that contain grapefruit.
Take bile acid resins, such as cholestyramine, colesevelam, or colestipol, at a different time of day than this medication. Take this medication at least 4 hours before or 4 hours after the bile acid resin.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
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Do not take this medication with any of the following:
-Aprepitant, fosaprepitant
-Avacopan
-Berotralstat
-Conivaptan
-Grapefruit and foods or drinks that contain grapefruit
-Levoketoconazole
-Lonafarnib
-Nirogacestat
-Rilzabrutinib
-Ritlecitinib
-Some antibiotics, such as ciprofloxacin, clarithromycin, erythromycin
-Some antiviral medications for HIV or hepatitis
-Some medications for blood pressure or angina, such as diltiazem or verapamil
-Some medications for cancer, such as adagrasib, ceritinib, crizotinib, duvelisib, fedratinib, imatinib, nilotinib, ribociclib, tucatinib
-Some medications for depression, such as fluvoxamine or nefazodone
-Some medications for fungal infections, such as fluconazole, isavuconazonium, itraconazole, ketoconazole, posaconazole, voriconazole
-Voxelotor
This medication may also interact with the following:
-Acetaminophen
-Alcohol
-Estrogen and progestin hormones
-Isotretinoin
-Methotrexate
-Some other medications for cholesterol, such as cholestyramine, colestipol, lovastatin, simvastatin
-Supplements, such as ginkgo biloba
-Warfarin
This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medication.
Taking this medication is only part of a total heart healthy program. Ask your care team if there are other changes you can make to improve your overall health.
Drinking alcohol with this medication can increase the risk of side effects. Do not have more than 1 alcoholic drink each day while taking this medication.
Talk to your care team if you may be pregnant. Serious fetal side effects can occur if you take this medication during pregnancy. You will need a negative pregnancy test before starting this medication. Estrogen and progestin hormones may not work as well while you are taking this medication. Contraception is recommended while taking this medication and for 2 weeks after the last dose. Your care team can help you find the option that works for you.
Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.
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If you miss a dose, skip it. Take your next dose at the normal time. Do not take double or extra doses.
Talk to your care team about what to do if you miss more than 7 days of your medication.
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Side effects that you should report to your care team as soon as possible:
-Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
-Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
-Constipation
-Diarrhea
-Gas
-Nausea
-Stomach pain
-Upset stomach
-Vomiting
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medication that is no longer needed or has expired:
-Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
-If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.
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